-------------------------------------------------------------------------------- Domain name : PF03381.7_CDC50 Domain size : 36 Domain Description : LEM3 (ligand-effect modulator 3) family / CDC50 family Domain gathering score : -143.3000 Domain trusted cutoff : -124.6000 Domain architecture : non-TM/SP [1 453], TM [454 495] -------------------------------------------------------------------------------- Example 1 gi|149751203|ref|XP_001489157.1| PREDICTED: similar to carbonic anhydrase XIV [Equus caballus] 336 (length) 297 324 .. (wrt seq) 460 495 .] (wrt HMM) No.of residues in non-TM/SP region : 0 [100%(over non-TM/SP length)] Scores for sequence family classification: Model Description Score E-value N -------- ----------- ----- ------- --- Carb_anhydrase Eukaryotic-type carbonic anhydrase 298.7 1.2e-86 1 CDC50 LEM3 (ligand-effect modulator 3) fami 17.7 7.1e-05 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Carb_anhydrase 1/1 22 278 .. 1 280 [] 298.7 1.2e-86 CDC50 1/1 297 325 .. 325 353 .] 17.7 7.1e-05 Alignments of top-scoring domains: Carb_anhydrase: domain 1 of 1, from 22 to 278: score 298.7, E = 1.2e-86 CS -SSTTTSCCCH.......HHTSGGGGS.GGGGSSSSSBEEECGGCEE *->WgYeegngpehhnnahPLWhklyPiAnGGnCqGeRQSPInIqtkkak W+Ye g +h W+ yP ++ + QSPInIqt + gi|1497512 22 WTYEGPHGQDH-------WPASYPECG-----SNAQSPINIQTDSVT 56 CS ETTTEEEEEEETTGGEEE. EEEEESSSEEEEEETSSSSSEEEETTTSSS yDPsLkpLslSYdaatake.feivNnGHsvqVefdDsddksvlsGGpLpg DP L +L+ ++++ +e+ + NnGH+vq +++ l G Lp gi|1497512 57 FDPELPALQPHGYDKPGTEpLDMHNNGHTVQLSLPP---ALYLEG--LPQ 101 CS EEEEEEEEEEES..STTTS-SSEETTBB-SEEEEEEEEEGTGGSSHHHHT pYRLkQfHFHWGGAssddqGSEHTVDGkkYaaELHLVHWNstKYssykeA Y + Q+H+HWG + GSEH ++ k+ aaELH+VH+ s Y s eA gi|1497512 102 KYVAAQLHLHWG-QKGAPGGSEHQINSKATAAELHIVHYDSDSYDSLSEA 150 CS TSTTSEEEEEEEEEESS.SS-GGGHHHHHHGGGGCSTTTEEEECSEEGGG vkkpDGLAVlGvFlkvGdykenpglqkvvDaLdsIktKGksatftnFDps ++ p GLAVlG++ ++G + np++ + +L +I++K+ +++ ++F++ gi|1497512 151 AQRPQGLAVLGILIEAG-ETKNPAYEHILGHLHEIRHKDEKTSVPPFNVG 199 CS GSSSSCCGCGEEEEEEE-SSTTT-SSEEEEEESSSEEEEHHHHHHHCTSB dLLPseeklrDYWtYpGSLTTPPltEsVtWiVlkepIsvSseQllkFRsL LLP +l +++Y GSLTTPP++ sV W+V+ ++S eQl+k+ gi|1497512 200 ELLPP--QLGQFFRYNGSLTTPPCYQSVLWTVFNQRAQISMEQLEKLQET 247 CS SSCTTSSS-BB...-------B--TTT--EEESS lfsaegeeevpcdimvdNyRPtQPLkgRvVrAsF<-* lfs ege+ + +v+NyR +QPL++R+V AsF gi|1497512 248 LFSTEGEPPEL---LVQNYRAPQPLNQRTVFASF 278 CDC50: domain 1 of 1, from 297 to 325: score 17.7, E = 7.1e-05 *->lvVGglclvlgivfliihlikpRklgDps<-* +vVG+lcl+l+++f++++++k R +s gi|1497512 297 IVVGCLCLLLAVYFIARKIRKKRLGSRKS 325 Example 2 gi|164687437|ref|ZP_02211465.1| hypothetical protein CLOBAR_01078 [Clostridium bartlettii DSM 16795]gi|164603211|gb|EDQ96676.1| hypothetical protein CLOBAR_01078 [Clostridium bartlettii DSM 16795] 285 (length) 242 272 .. (wrt seq) 458 495 .] (wrt HMM) No.of residues in non-TM/SP region : 0 [100%(over non-TM/SP length)] Scores for sequence family classification: Model Description Score E-value N -------- ----------- ----- ------- --- Abi CAAX amino terminal protease family 78.8 2.1e-21 1 CDC50 LEM3 (ligand-effect modulator 3) fami 17.8 6.7e-05 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Abi 1/1 131 220 .. 1 115 [] 78.8 2.1e-21 CDC50 1/1 242 272 .. 323 353 .] 17.8 6.7e-05 Alignments of top-scoring domains: Abi: domain 1 of 1, from 131 to 220: score 78.8, E = 2.1e-21 *->llilllvllaplaEElfFRGilltalerrlkkrytlfgpllaiiiss + ++l+v+ ap+ EElfFR +l+ +++ f++++ +i+ss gi|1646874 131 ASFILTVISAPILEELFFRVVLFKRISKF-------FNVYIGMILSS 170 liFallHlanalelgllliqpvlinwlqllytfllGlvlgllylrrtgsL l+F++lH+++a +++++++G+ +lyl + +++ gi|1646874 171 LLFGVLHMELA-----------------IVGAVIFGFANCILYL-KYRNI 202 lapilvHalnNligfill<-* l p+ vH+lnN+++ i gi|1646874 203 LIPMTVHFLNNFLVSIHT 220 CDC50: domain 1 of 1, from 242 to 272: score 17.8, E = 6.7e-05 *->aYlvVGglclvlgivfliihlikpRklgDps<-* aYl+ G++ +++g +++i++++k Rk+ + + gi|1646874 242 AYLILGAIVFIIGMILFIRFIVKNRKYIESD 272 Example 3 gi|123422284|ref|XP_001306144.1| polymorphic outer membrane protein [Trichomonas vaginalis G3]gi|121887702|gb|EAX93214.1| polymorphic outer membrane protein, putative [Trichomonas vaginalis G3] 569 (length) 479 512 .. (wrt seq) 457 495 .] (wrt HMM) No.of residues in non-TM/SP region : 0 [100%(over non-TM/SP length)] Scores for sequence family classification: Model Description Score E-value N -------- ----------- ----- ------- --- Chlam_PMP Chlamydia polymorphic membrane protei 41.6 4.9e-10 4 CDC50 LEM3 (ligand-effect modulator 3) fami 14.4 0.00065 1 DUF916 Bacterial protein of unknown function 7.7 0.049 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Chlam_PMP 1/4 72 96 .. 1 19 [] 11.6 0.072 Chlam_PMP 2/4 108 125 .. 1 19 [] 10.2 0.18 Chlam_PMP 3/4 133 151 .. 1 19 [] 8.7 0.44 Chlam_PMP 4/4 171 188 .. 1 18 [. 11.1 0.1 CDC50 1/1 479 511 .. 322 353 .] 14.4 0.00065 DUF916 1/1 469 509 .. 327 368 .] 7.7 0.049 Alignments of top-scoring domains: Chlam_PMP: domain 1 of 4, from 72 to 96: score 11.6, E = 0.072 *->ditFsgNsa......aggGGAiyas<-* ++Fs+N a ++ ag GGAi+ s gi|1234222 72 KTEFSNNYAfcagsaAGIGGAIFIS 96 Chlam_PMP: domain 2 of 4, from 108 to 125: score 10.2, E = 0.18 *->ditFsgNsaaggGGAiyas<-* +i+F +N+a + GG+i + gi|1234222 108 SIIFKKNEA-SVGGGIASL 125 Chlam_PMP: domain 3 of 4, from 133 to 151: score 8.7, E = 0.44 *->ditFsgNsaaggGGAiyas<-* +tFsgN+a + GGAiy + gi|1234222 133 KVTFSGNTAFKYGGAIYYQ 151 Chlam_PMP: domain 4 of 4, from 171 to 188: score 11.1, E = 0.1 *->ditFsgNsaaggGGAiya<-* d+tF +N+a++ GGA+ a gi|1234222 171 DCTFRNNAAYELGGAVAA 188 CDC50: domain 1 of 1, from 479 to 511: score 14.4, E = 0.00065 *->IaYlvVGglclvlgivfliihli.kpRklgDps<-* I++++VG++c + i+++++++i ++Rk ++ gi|1234222 479 IIWIIVGCVCGAILIGLILAFFIiRSRKSNEEE 511 DUF916: domain 1 of 1, from 469 to 509: score 7.7, E = 0.049 *->NqkaVtkkkkdnnWllyiiiglllllllllivyliwkrkkkk<-* N kk +++W++ + + +l+ l+l++++i+ rk ++ gi|1234222 469 NAANPRKK-TSIIWIIVGCVCGAILIGLILAFFIIRSRKSNE 509 Example 4 gi|73981547|ref|XP_540298.2| PREDICTED: similar to carbonic anhydrase XIV precursor [Canis familiaris] 337 (length) 298 325 .. (wrt seq) 460 495 .] (wrt HMM) No.of residues in non-TM/SP region : 0 [100%(over non-TM/SP length)] Scores for sequence family classification: Model Description Score E-value N -------- ----------- ----- ------- --- Carb_anhydrase Eukaryotic-type carbonic anhydrase 290.3 4.2e-84 1 CDC50 LEM3 (ligand-effect modulator 3) fami 13.7 0.00098 1 HAMP HAMP domain 9.1 0.099 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Carb_anhydrase 1/1 23 279 .. 1 280 [] 290.3 4.2e-84 CDC50 1/1 298 326 .. 325 353 .] 13.7 0.00098 HAMP 1/1 294 318 .. 1 25 [. 9.1 0.099 Alignments of top-scoring domains: Carb_anhydrase: domain 1 of 1, from 23 to 279: score 290.3, E = 4.2e-84 CS -SSTTTSCCCH.......HHTSGGGGS.GGGGSSSSSBEEECGGCEE *->WgYeegngpehhnnahPLWhklyPiAnGGnCqGeRQSPInIqtkkak W+Y g +h W+ P ++ + QSPI+Iqt + gi|7398154 23 WTYVGPHGQDH-------WPASHPECG-----SNAQSPIDIQTDSVT 57 CS ETTTEEEEEEETTGGEEE. EEEEESSSEEEEEETSSSSSEEEETTTSSS yDPsLkpLslSYdaatake.feivNnGHsvqVefdDsddksvlsGGpLpg DP L +L+l +++ +e+ + NnGH+vq +++ l G Lp gi|7398154 58 FDPELPALQLQGYDQPGTEpLDLHNNGHTVQLSLPP---TMYLEG--LPR 102 CS EEEEEEEEEEES..STTTS-SSEETTBB-SEEEEEEEEEGTGGSSHHHHT pYRLkQfHFHWGGAssddqGSEHTVDGkkYaaELHLVHWNstKYssykeA Y + Q+H+HWG +GSEH ++G++ aaELH+VH+ s Y s +eA gi|7398154 103 KYVAAQLHLHWG-ETGSLRGSEHQINGEATAAELHIVHYDSDSYDSLGEA 151 CS TSTTSEEEEEEEEEESS.SS-GGGHHHHHHGGGGCSTTTEEEECSEEGGG vkkpDGLAVlGvFlkvGdykenpglqkvvDaLdsIktKGksatftnFDps + kp GLAVlG++ +vG + np + +++L +I++K+++++ ++F++ gi|7398154 152 APKPQGLAVLGILIEVG-EAKNPVYEHILSHLHEIRHKDQKTSVPPFNVG 200 CS GSSSSCCGCGEEEEEEE-SSTTT-SSEEEEEESSSEEEEHHHHHHHCTSB dLLPseeklrDYWtYpGSLTTPPltEsVtWiVlkepIsvSseQllkFRsL LLP +l +++Y GSLTTPP++ sV W+V+ ++S Ql+++ gi|7398154 201 ELLPP--QLNQFFRYNGSLTTPPCYQSVLWTVFNRRAQISMGQLEELQET 248 CS SSCTTSSS-BB...-------B--TTT--EEESS lfsaegeeevpcdimvdNyRPtQPLkgRvVrAsF<-* lfs e e+ + +v+NyR +QPL++R+V AsF gi|7398154 249 LFSTEEEPSKL---LVRNYRAPQPLNQRTVFASF 279 CDC50: domain 1 of 1, from 298 to 326: score 13.7, E = 0.00098 *->lvVGglclvlgivfliihlikpRklgDps<-* + VG+lcl+l+++f++++++k R + ++ gi|7398154 298 ILVGCLCLLLAVYFIARKIRKKRLGNRKT 326 HAMP: domain 1 of 1, from 294 to 318: score 9.1, E = 0.099 CS HHHHHHHHHHHHHHHHHH-XXXXXX *->lllvllialllalllalllarrilr<-* l++++l+++l +ll+++++ar i + gi|7398154 294 LGVGILVGCLCLLLAVYFIARKIRK 318 Example 5 gi|194036285|ref|XP_001924916.1| PREDICTED: similar to carbonic anhydrase 14 [Sus scrofa] 233 (length) 194 221 .. (wrt seq) 460 495 .] (wrt HMM) No.of residues in non-TM/SP region : 0 [100%(over non-TM/SP length)] Scores for sequence family classification: Model Description Score E-value N -------- ----------- ----- ------- --- Carb_anhydrase Eukaryotic-type carbonic anhydrase 108.0 3.7e-31 1 CDC50 LEM3 (ligand-effect modulator 3) fami 14.5 0.00058 1 HAMP HAMP domain 9.1 0.099 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Carb_anhydrase 1/1 85 175 .. 185 280 .] 108.0 3.7e-31 CDC50 1/1 194 222 .. 325 353 .] 14.5 0.00058 HAMP 1/1 190 214 .. 1 25 [. 9.1 0.099 Alignments of top-scoring domains: Carb_anhydrase: domain 1 of 1, from 85 to 175: score 108.0, E = 3.7e-31 CS TEEEECSEEGGGGSSSSCCGCGEEEEEEE-SSTTT-SSEEEEEESSS *->GksatftnFDpsdLLPseeklrDYWtYpGSLTTPPltEsVtWiVlke +++++ ++F++++LLP +l +++Y GSLTTPP++ sV W+V+ gi|1940362 85 DQRTSVPPFNVRGLLPP--LLAQFFRYNGSLTTPPCYQSVLWTVFNR 129 CS EEEEHHHHHHHCTSBSSCTTSSS-BB...-------B--TTT--EEESS pIsvSseQllkFRsLlfsaegeeevpcdimvdNyRPtQPLkgRvVrAsF< ++S Ql+k+ lfs e e+ + +v+NyR +QPL++R V AsF gi|1940362 130 RAQISMGQLEKLQEALFSTEEEPSQL---LVQNYRAPQPLNQRIVLASF 175 CS -* gi|1940362 - - CDC50: domain 1 of 1, from 194 to 222: score 14.5, E = 0.00058 *->lvVGglclvlgivfliihlikpRklgDps<-* + VG+lcl+l+++f++++++k R + +s gi|1940362 194 ILVGCLCLLLAVYFIARKIRKKRLGNRKS 222 HAMP: domain 1 of 1, from 190 to 214: score 9.1, E = 0.099 CS HHHHHHHHHHHHHHHHHH-XXXXXX *->lllvllialllalllalllarrilr<-* l++++l+++l +ll+++++ar i + gi|1940362 190 LGVGILVGCLCLLLAVYFIARKIRK 214