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Domain name : PF01299.9_Lamp
Domain size : 338
Domain gathering score : -87.0000
Domain gathering score(TMSP) : 18.34
Domain gathering score(non-TMSP) : -95.8
Domain architecture : TM/SP [304 338], non-TM/SP [1 303]
Total query sequences in database : 164
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A8PS51 A8PS51_BRUMA LAMP family protein lmp-1, putative [Brugia malayi]
Lamp         Lysosome-associated membrane glycoprotei   -82.3     0.0006   1
Lamp           1/1       1   184 []     1   338 []   -82.3   0.0006
Lamp: domain 1 of 1, from 1 to 184: score -82.3, E = 0.0006
                   *->YsvteltfsynlsDttlFPnatskgvkTvtsstdaikaptnttyrCv
                           +++ +  s++ +  n +  g  + +    ++++         
      A8PS51     1    -----MILKSDNSTEQFKFNISGRGDGSCK----GTQHI-------- 30   

                   ssttvpmtnVtvtfsDvtlqAylqngtfSktetrCeaDktpTpsPttaPt
                      +++ +                                          
      A8PS51    31 ---YISFN------------------------------------------ 35   

                   tapapstVaTpvPsPtttPvPssPavGnYsVtngNgtyCLLAsMGLQLNi
                                sP                +n   t        L + +
      A8PS51    36 -------------SPV-------------GLKN--ST--------LAIHF 49   

                   tyekkdnktvtrlfNInPnkTtasGsCgsqtatLeLlWGsfengtvLtft
                   ++  kd+ +      + +n T            L      fe++      
      A8PS51    50 KQ--KDDSF------LISNFT------------LAV---YFEQK------ 70   

                   FtlnnssskfyLseVslsltlldesfpdasenptFsasNssLsalqapvG
                     ln++         sl+++l       + +   +   + s     a+ +
      A8PS51    71 --LNST--------ESLHMYL-------MDK---HAELDVS-----ASSN 95   

                   sSYkCnkeQslqvseafqeellalntfnLqVQAFnvtgnkkFstaeE...
                     YkC+ e  l+           +++ n+++ A    +++ F + +E + 
      A8PS51    96 GAYKCS-ETILSFEGGSA-----VTLHNVRLTAYAHFNTTEFPENQEyni 139  

                   CslDdn.smLiPIaVGaALaGLvliVLIAYlIGRrRsharGYQti<-*
                   C+lD  +s+L+PI+VG +La Lv+iVLIAYl+GR R  + GY ++   
      A8PS51   140 CQLDVRtSDLVPIVVGVCLAALVIIVLIAYLVGRARAKRQGYASV    184  

TMSP/non-TMSP/fixed score (recomputed/original total): 66.527/-136.055/-13.543 (-83.071/-82.3)


Q11117 LMP1_CAEEL LAMP family protein lmp-1 [Caenorhabditis elegans]
Lamp       Lysosome-associated membrane glycoprotein    -85.1    0.00086   1
Lamp         1/1       1   237 []     1   338 []   -85.1  0.00086
Lamp: domain 1 of 1, from 1 to 237: score -85.1, E = 0.00086
                   *->YsvteltfsynlsDttlFPnatskgvkTvtsstdaikaptnttyrCv
                        ++ +++   l  ++    at+++   ++++t ++ + ++  ++ +
      Q11117     1    MLKSFVILFAFLASAS----ATASHYYVTNNNTGLTCIILDGDFQFN 43   

                   ssttvpmtnVtvtfsDvtlqAylqngtfSktetrCeaDktpTpsPttaPt
                          t                                          
      Q11117    44 LVFNEKNT------------------------------------------ 51   

                   tapapstVaTpvPsPtttPvPssPavGnYsVtngNgtyCLLAsMGLQLNi
                                  t           + +Vt+ N+t            +
      Q11117    52 ---------------T----------EKFTVTF-NET------------V 63   

                   tyekkdnktvtrlfNInPnkTtasGsCgsqtatLeLlWGsfengtvLtft
                   + e  d + v+    ++  +++++    ++ ++ +      ++ + L+ +
      Q11117    64 SVEG-DCNGVRNNQSVQTLNIKFN----PEGQSARY----AKE-WELDIV 103  

                   FtlnnssskfyLseVslsltlldesfpdasenptFsasNssLsalqapvG
                   F+ ++    +  + +  +lt    + +     ++   +N       a+  
      Q11117   104 FGSSS---NVAFEIIDYTLTTQRTDLVPYFG-KFVRDANAA-GDVTATQT 148  

                   sSYkCnkeQslqvse..afqeellalntfnLqVQAFnvtgnkkFst..ae
                   + YkC+   +l +  +++++     ++t+n+   AF   +++ F t++++
      Q11117   149 NAYKCS-TAKLGLVGgsTID-----IKTSNVI--AFAQMNGTVFPTdqVY 190  

                   E.CslDdn.smLiPIaVGaALaGLvliVLIAYlIGRrRsharGYQti<-*
                   E C lD  ++ ++PI+VGa+La Lv++VL+ YlIGR R  + GY ++   
      Q11117   191 EvCYLDARtNEVVPIVVGACLAALVVVVLVGYLIGRARAKRQGYASV    237  

TMSP/non-TMSP/fixed score (recomputed/original total): 61.848/-138.332/-9.542 (-86.026/-85.1)


nonTMSP insignificant hits/no hmmpfamresult hits (total %) :2/12 (14 8.5%)